Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.
about
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signalingInteraction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowthKinase activation through dimerization by human SH2-BSH2-B is required for both male and female reproductionDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaRecent advances in understanding leptin signaling and leptin resistanceJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Leptin signaling and leptin resistanceTyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activityAutophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activitySH2-Bbeta is a Rac-binding protein that regulates cell motilityJAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functionsLnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkTyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B betaLnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesInteraction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activationThe SH2B gene is associated with serum leptin and body fat in normal female twins.Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesityA bipolar clamp mechanism for activation of Jak-family protein tyrosine kinasesThe Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.SH2B1 regulation of energy balance, body weight, and glucose metabolism.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis.SH2-B family members differentially regulate JAK family tyrosine kinases.Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.Jak2 is involved in c-Myc induction by Bcr-Abl.YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signalingGrowth hormone signal transduction.JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in miceAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activationNeuronal SH2B1 is essential for controlling energy and glucose homeostasis.Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion.Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals.Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.
P2860
Q24304330-1DA2622D-78E2-4C5D-9DF9-496BCB47B6CCQ24311524-9692FC4C-C182-486B-8B9B-2FA434BB0E5CQ24519086-9136017B-F929-4157-B0AD-070557F146B2Q24537266-1B5F5F2B-5977-4E1F-9171-A88199012D43Q24554240-9131BDBC-0102-45AE-984C-720CDCE5757EQ24658188-B18234B5-86AA-4359-B90A-E1AA542EC6ECQ24806655-DCB9FD28-B9EC-4132-8E36-1786C9B2C4D5Q26865174-2C69E80C-4ABF-42C3-B6A9-031F3FB53248Q28115584-A4F0D83D-D5D1-4DE6-8A33-5A27B09EEDD3Q28116068-98CC2706-78E7-4E41-8FAD-5ED46B4560DFQ28215233-397FAF05-3316-471B-A300-4E4E49F5F579Q28242536-AEA1CC04-60A0-494C-ACB3-7FDB5C288CC0Q28306960-3C93C4FD-0EC1-4727-B0DD-ED885D590620Q28473245-35760BAE-3784-4511-96B7-5C01834113A2Q28506708-C805B9EE-E17C-447C-86EF-AC9D0C480304Q28508573-CF54C05C-F2A8-40D6-9085-A6207A4EA250Q28570430-A2F6A4BF-B777-493E-8E78-979148337AE2Q28592322-863216ED-A36C-4745-9910-4190F2B70174Q30359262-536E0EDF-D2EF-4E9B-B1BA-F2A0B5480618Q31001636-40B48B89-E6AD-4E2C-B1F4-9D2DFD5C999EQ33349224-87E17B57-E1DE-4516-8AC3-FCB76B49AAEFQ33432720-300F2C2F-C979-4E4C-94C0-7113A1015C89Q33493398-6238ED25-A0B2-440E-9C16-1F1367D04232Q34023575-DBC0B9E6-4C55-42E1-865F-68B9A552DAC8Q34058582-5116066F-14AD-4FEA-8479-3E872B631F0FQ34084020-286508B7-EA4B-42D8-9F79-CBE7284E9760Q34105915-C1ABD7B8-3E1F-4B18-86FB-7345A4491740Q34132466-CD27550F-EF9D-4942-AFB9-AF7E54981367Q34153616-671B8A02-1197-4188-9A06-C070CA659BBDQ34173102-AACD53D6-C7B9-4C28-BDE1-3E5EFA521EB8Q34598039-46BBFC80-7C25-4AA4-BE9C-41C9FF589F65Q34722214-BEE7CCD5-B47A-4E83-A65D-BFE8EFA5E893Q34968444-B8887CDC-14EC-4430-B411-6B2EC1A43264Q35073042-DCFEEA87-33B5-4528-9977-FF1817F58B45Q35073608-8822E64C-CBDB-4F53-A61B-E4D2421C1B09Q35165261-054DCED6-0221-421D-A985-6662361A16D4Q35576170-6F615240-E71E-4D52-80C9-911AF40E935EQ35913642-A0ECA359-AF5D-4F3D-85D5-9E436669BA59Q36007570-B6214590-4B1F-4DB8-B93C-36C324CF3CF2Q36078608-43BB1B1E-FDE6-4DF2-A479-CBBE9EA2E032
P2860
Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@ast
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@en
type
label
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@ast
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@en
prefLabel
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@ast
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@en
P2860
P356
P1476
Identification of SH2-bbeta as ...... yrosine kinase Janus kinase 2.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.13.7172
P407
P577
1999-06-01T00:00:00Z