Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis.
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Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganismsHyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell ExteriorInsights into the structure and function of membrane-integrated processive glycosyltransferases.In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activityThe streptococcal hyaluronan synthases are inhibited by sulfhydryl-modifying reagents, but conserved cysteine residues are not essential for enzyme function.Site-directed mutation of conserved cysteine residues does not inactivate the Streptococcus pyogenes hyaluronan synthase.Topological organization of the hyaluronan synthase from Streptococcus pyogenes.Mutation of two intramembrane polar residues conserved within the hyaluronan synthase family alters hyaluronan product size.The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer.The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.Hyaluronic acid production in Bacillus subtilisQuantitative continuous assay for hyaluronan synthaseSimple primary structure, complex turnover regulation and multiple roles of hyaluronan.Identification of a membrane-localized cysteine cluster near the substrate-binding sites of the Streptococcus equisimilis hyaluronan synthaseHyaluronan synthase mediates dye translocation across liposomal membranes.Clustered Conserved Cysteines in Hyaluronan Synthase Mediate Cooperative Activation by Mg(2+) Ions and Severe Inhibitory Effects of Divalent CationsHyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteinesHyaluronan and homeostasis: a balancing act.Characterization of the purified hyaluronan synthase from Streptococcus equisimilis.Hyaluronan biosynthesis by class I streptococcal hyaluronan synthases occurs at the reducing end.Hyaluronan synthase assembles chitin oligomers with -GlcNAc(α1→)UDP at the reducing end.Anionic lipids enriched at the ExPortal of Streptococcus pyogenes.Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of AktAllosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction.Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancerInsight into hyaluronic acid molecular weight control.Cloning and characterization of the phosphatidylserine synthase gene of Agrobacterium sp. strain ATCC 31749 and effect of its inactivation on production of high-molecular-mass (1-->3)-beta-D-glucan (curdlan).Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.Hyaluronan synthesis induces microvillus-like cell surface protrusions.Tts, a processive beta-glucosyltransferase of Streptococcus pneumoniae, directs the synthesis of the branched type 37 capsular polysaccharide in Pneumococcus and other gram-positive species.Functional molecular mass of a vertebrate hyaluronan synthase as determined by radiation inactivation analysis.Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone.An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif.Engineering of cell membrane to enhance heterologous production of hyaluronic acid in Bacillus subtilis.Biotechnological production of hyaluronic acid: a mini review.Phospholipid dependence and liposome reconstitution of purified hyaluronan synthase.
P2860
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P2860
Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Purification and lipid depende ...... and Streptococcus equisimilis.
@ast
Purification and lipid depende ...... and Streptococcus equisimilis.
@en
type
label
Purification and lipid depende ...... and Streptococcus equisimilis.
@ast
Purification and lipid depende ...... and Streptococcus equisimilis.
@en
prefLabel
Purification and lipid depende ...... and Streptococcus equisimilis.
@ast
Purification and lipid depende ...... and Streptococcus equisimilis.
@en
P2093
P2860
P356
P1476
Purification and lipid depende ...... and Streptococcus equisimilis.
@en
P2093
Baggenstoss BA
Tlapak-Simmons VL
P2860
P304
P356
10.1074/JBC.274.7.4239
P407
P577
1999-02-01T00:00:00Z