Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.
about
c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damageInduction of colonic epithelial cell apoptosis by p47-dependent oxidantsWerner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionMechanisms of Nuclear Export in Cancer and Resistance to ChemotherapyKinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsNuclear PI3K signaling in cell growth and tumorigenesisNuclear export of proteins and drug resistance in cancerMicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia CellsAntileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsNovel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.p53-Dependent anticancer effects of leptomycin B on lung adenocarcinomaCan an infectious disease genomics project predict and prevent the next pandemic?Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.Caspase-dependent cleavage of c-Abl contributes to apoptosis.Subcellular distribution of p210(BCR-ABL) in CML cell lines and primary CD34+ CML cells.Imatinib: a breakthrough of targeted therapy in cancer.c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin.Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL.Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies.PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.Targeting nucleocytoplasmic transport in cancer therapyInhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsChronic myeloid leukemia: a minimalistic view of post-therapeutic monitoringCombination therapy with imatinib mesylate (STI571): synopsis of in vitro studies.STI-571 in chronic myelogenous leukaemia.Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Resistance of Philadelphia-chromosome positive leukemia towards the kinase inhibitor imatinib (STI571, Glivec): a targeted oncoprotein strikes back.Molecular genetic events in adult acute lymphoblastic leukemia.Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies.Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemiaMUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cellsThe Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cellsMolecular biological design of novel antineoplastic therapies.Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Cell death signaling and anticancer therapyActivation of abl family kinases in solid tumors.Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease?
P2860
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P2860
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@ast
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@en
type
label
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@ast
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@en
prefLabel
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@ast
Induction of apoptosis in chro ...... nt of BCR-ABL tyrosine kinase.
@en
P356
P1433
P1476
Induction of apoptosis in chro ...... ent of BCR-ABL tyrosine kinase
@en
P2093
P2888
P304
P356
10.1038/84683
P407
P577
2001-02-01T00:00:00Z
P5875
P6179
1009633396