Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis.
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Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptasesComparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.Influence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequencies.Fidelity of retrotransposon replication.Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelityY586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template.Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.New human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) mutants with increased fidelity of DNA synthesis. Accuracy, template binding, and processivity.A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesisSubstitution of a residue contacting the triphosphate moiety of the incoming nucleotide increases the fidelity of yeast DNA polymerase zeta.A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity.Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase.Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection.Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase.
P2860
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P2860
Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis.
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@ast
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@en
type
label
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@ast
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@en
prefLabel
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@ast
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@en
P2093
P356
P1433
P1476
Fidelity of mutant HIV-1 rever ...... the accuracy of DNA synthesis.
@en
P2093
P304
P356
10.1021/BI972672G
P407
P577
1998-04-01T00:00:00Z