Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity
about
Thermostable DNA polymerase from a viral metagenome is a potent RT-PCR enzymeRole of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidineStructural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switchingUtilization of nonviral sequences for minus-strand DNA transfer and gene reconstitution during retroviral replication.Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication.Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity.Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.Retrovirus reverse transcriptases containing a modified YXDD motif.Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer.Structure-based moloney murine leukemia virus reverse transcriptase mutants with altered intracellular direct-repeat deletion frequencies.RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication.
P2860
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P2860
Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity
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2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Development of an in vivo assa ...... riptase important for fidelity
@ast
Development of an in vivo assa ...... riptase important for fidelity
@en
type
label
Development of an in vivo assa ...... riptase important for fidelity
@ast
Development of an in vivo assa ...... riptase important for fidelity
@en
prefLabel
Development of an in vivo assa ...... riptase important for fidelity
@ast
Development of an in vivo assa ...... riptase important for fidelity
@en
P2093
P2860
P1433
P1476
Development of an in vivo assa ...... riptase important for fidelity
@en
P2093
E K Halvas
E S Svarovskaia
V K Pathak
P2860
P304
P356
10.1128/JVI.74.14.6669-6674.2000
P577
2000-01-01T00:00:00Z