Targeting ceramide metabolism--a strategy for overcoming drug resistance.
about
Killing tumours by ceramide-induced apoptosis: a critique of available drugsRoles of bioactive sphingolipids in cancer biology and therapeuticsA house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell deathPlant sterols as anticancer nutrients: evidence for their role in breast cancerTamoxifen regulation of sphingolipid metabolism--Therapeutic implicationsHuman Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNAPerceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal StudyA new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosisRole of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.Dynamics of ceramide generation and metabolism in response to fenretinide--Diversity within and among leukemiaModification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.Gaucher disease: unmet treatment needs.Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinomaCeramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.Incorporation of Fluorescence Ceramide-Based HPLC Assay for Rapidly and Efficiently Assessing Glucosylceramide Synthase In Vivo.Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.Doxorubicin, DNA torsion, and chromatin dynamics.Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines.Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.Regulating survival and development in the retina: key roles for simple sphingolipids.Targeting apoptosis in cancer chemotherapy.Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance.Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.Apoptotic sphingolipid ceramide in cancer therapy.Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells.Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cellsRecent advances in the immunobiology of ceramide.Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer.Mechanisms and strategies to overcome multiple drug resistance in cancer.Sphingolipids: regulators of crosstalk between apoptosis and autophagyEffects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells.Sphingolipids in cancer: regulation of pathogenesis and therapy.Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cellsTamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production
P2860
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P2860
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@ast
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@en
type
label
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@ast
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@en
prefLabel
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@ast
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@en
P2093
P356
P1476
Targeting ceramide metabolism--a strategy for overcoming drug resistance.
@en
P2093
P304
P356
10.1093/JNCI/93.5.347
P407
P577
2001-03-01T00:00:00Z