Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.
about
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsEarly steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsAPE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instabilityInhibition of Ape1 nuclease activity by lead, iron, and cadmium.Isolation of a small molecule inhibitor of DNA base excision repair.Pathways for repairing and tolerating the spectrum of oxidative DNA lesionsBase excision repair and cancerAP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesisEndogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisGenotoxicants target distinct molecular networks in neonatal neuronsRapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activationDNA repair modulates the vulnerability of the developing brain to alkylating agentsApurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.Two essential but distinct functions of the mammalian abasic endonuclease.Mitochondrial base excision repair assaysBase excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice.Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitisUncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.Base excision repair capacity in informing healthspan.Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Mechanism and regulation of class switch recombinationDual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionIdentification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityReduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (APE1) Variants on Nucleosomes: IDENTIFICATION OF ACCESS RESIDUES.Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.A gene encoding an apurinic/apyrimidinic endonuclease-like protein is up-regulated in human gastric cancer.APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary AgentsActivities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan.Capturing snapshots of APE1 processing DNA damage.Folate and colorectal cancer in rodents: a model of DNA repair deficiency.Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: implications for assessing DNA repair capacity in humansApurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
P2860
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P2860
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@ast
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@en
type
label
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@ast
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@en
prefLabel
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@ast
Heterozygosity for the mouse A ...... ociated with oxidative stress.
@en
P2093
P1433
P1476
Heterozygosity for the mouse A ...... sociated with oxidative stress
@en
P2093
E C Friedberg
R E Hammer
R L Daniel
P304
P407
P577
2001-07-01T00:00:00Z