Isolation of a small molecule inhibitor of DNA base excision repair.
about
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainGenome-wide reprogramming in the mouse germ line entails the base excision repair pathwayRedox-directed cancer therapeutics: molecular mechanisms and opportunitiesLinking uracil base excision repair and 5-fluorouracil toxicity in yeastDNA repair targeted therapy: The past or future of cancer treatment?Active DNA demethylation in post-mitotic neurons: a reason for optimismDouble threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine-thymine mismatchTargeted cancer therapies based on the inhibition of DNA strand break repairCockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediatesIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionCross-talk-free dual-color fluorescence cross-correlation spectroscopy for the study of enzyme activity.Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Polymer-based dense fluidic networks for high throughput screening with ultrasensitive fluorescence detection.Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.Single cell trapping and DNA damage analysis using microwell arrays.Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein bindingApurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathySmall molecule inhibitors of DNA repair nuclease activities of APE1.Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsSaccharomyces cerevisiae as a model system to study the response to anticancer agents.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsPoly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesDefining a genotoxic profile with mouse embryonic stem cellsBase excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondiiInhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesDesign and activity of AP endonuclease-1 inhibitors.Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Polymorphisms in DNA repair genes of XRCC1, XPA, XPC, XPD and associations with lung cancer risk in Chinese peopleBase excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsDevelopment of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk.
P2860
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P2860
Isolation of a small molecule inhibitor of DNA base excision repair.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Isolation of a small molecule inhibitor of DNA base excision repair
@nl
Isolation of a small molecule inhibitor of DNA base excision repair.
@ast
Isolation of a small molecule inhibitor of DNA base excision repair.
@en
type
label
Isolation of a small molecule inhibitor of DNA base excision repair
@nl
Isolation of a small molecule inhibitor of DNA base excision repair.
@ast
Isolation of a small molecule inhibitor of DNA base excision repair.
@en
prefLabel
Isolation of a small molecule inhibitor of DNA base excision repair
@nl
Isolation of a small molecule inhibitor of DNA base excision repair.
@ast
Isolation of a small molecule inhibitor of DNA base excision repair.
@en
P2093
P2860
P356
P1476
Isolation of a small molecule inhibitor of DNA base excision repair
@en
P2093
Denis C Talbot
Fiona Smart
Grigory L Dianov
Ian D Hickson
Jason L Parsons
Laurence Gardiner
Paul A Freemont
Paul Shrimpton
Sue Houlbrook
Timothy Hammonds
P2860
P304
P356
10.1093/NAR/GKI781
P407
P577
2005-08-19T00:00:00Z