Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
about
Thyrotropin releasing hormone (TRH) affects gene expression in pancreatic beta-cellsInflammatory response in islet transplantation.A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survivalInduction of protective genes leads to islet survival and function.Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation.Nonhuman primate models in type 1 diabetes research.Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.Gene therapy for autoimmune diseases: quo vadis?XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury.Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.Cytoprotection of beta cells: rational gene transfer strategies.Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell deathRapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis.The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?Induction of beta-cell resistance to hypoxia and technologies for oxygen delivery to transplanted pancreatic islets.Anti-inflammatory strategies to enhance islet engraftment and survival.Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis.Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.Co-encapsulation of bioengineered IGF-II-producing cells and pancreatic islets: effect on beta-cell survival.Beneficial effects of desferrioxamine on encapsulated human islets--in vitro and in vivo study.A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes.A20 inhibits oxidized low-density lipoprotein-induced apoptosis through negative Fas/Fas ligand-dependent activation of caspase-8 and mitochondrial pathways in murine RAW264.7 macrophages.Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after TransplantTumor necrosis factor α-induced protein-3 protects zinc transporter 8 against proinflammatory cytokine-induced downregulation.Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets.A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB activity in pancreatic islets depends on oxygen availability.Human islets express a marked proinflammatory molecular signature prior to transplantation.Low-dose rapamycin unmasks the protective potential of targeting intragraft NF-κB for islet transplants.Anti-inflammatory and anti-osteoclastogenic effects of zinc finger protein A20 overexpression in human periodontal ligament cells.Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcomeExpression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets PostisolationThe Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions
P2860
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P2860
Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Genetic engineering of a subop ...... s beta cell mass and function.
@ast
Genetic engineering of a subop ...... s beta cell mass and function.
@en
type
label
Genetic engineering of a subop ...... s beta cell mass and function.
@ast
Genetic engineering of a subop ...... s beta cell mass and function.
@en
prefLabel
Genetic engineering of a subop ...... s beta cell mass and function.
@ast
Genetic engineering of a subop ...... s beta cell mass and function.
@en
P2093
P1476
Genetic engineering of a subop ...... s beta cell mass and function.
@en
P2093
Christiane Ferran
Christopher Longo
Maria B Arvelo
Shane T Grey
Soizic Daniel
Tala Shukri
Vaja Tchipashvili
Virendra I Patel
P304
P356
10.4049/JIMMUNOL.170.12.6250
P407
P577
2003-06-01T00:00:00Z