DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions.
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Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping.Combination reactions of superoxide with 8-Oxo-7,8-dihydroguanine radicals in DNA: kinetics and end products.Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage.Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesionsThe role of one-electron reduction of lipid hydroperoxides in causing DNA damageCharacterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contextsComparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cellsMechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions.Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).Guanine-specific oxidation of double-stranded DNA by Cr(VI) and ascorbic acid forms spiroiminodihydantoin and 8-oxo-2'-deoxyguanosine.Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoin.Generation of guanine-thymidine cross-links in DNA by peroxynitrite/carbon dioxideMechanistic aspects of hydration of guanine radical cations in DNA.Lifetimes and reaction pathways of guanine radical cations and neutral guanine radicals in an oligonucleotide in aqueous solutions.Structural, energetic and dynamic properties of guanine(C8)-thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair.Oxidation of guanine by carbonate radicals derived from photolysis of carbonatotetramminecobalt(III) complexes and the pH dependence of intrastrand DNA cross-links mediated by guanine radical reactions.Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg VirusSolvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contextsOxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosinesGuanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.Chemical and electrochemical oxidation of C8-arylamine adducts of 2'-deoxyguanosineLesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies.Methylation of 2'-deoxyguanosine by a free radical mechanism.Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.Removal of oxidatively generated DNA damage by overlapping repair pathways.Formation and processing of DNA damage substrates for the hNEIL enzymes.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.Formation of 8-oxo-7,8-dihydroguanine-radicals in gamma-irradiated DNA by multiple one-electron oxidations.DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants.Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite.Characterization of G-rich and T-rich oligonucleotides using ion-pair reversed-phase high-performance liquid chromatography/tandem electrospray ionization mass spectrometry.Superoxide dismutase 1-mediated production of ethanol- and DNA-derived radicals in yeasts challenged with hydrogen peroxide: molecular insights into the genome instability of peroxiredoxin-null strains.Efficacy and site specificity of hydrogen abstraction from DNA 2-deoxyribose by carbonate radicals.Use of short duplexes for the analysis of the sequence-dependent cleavage of DNA by a chemical nuclease, a manganese porphyrin.Guanine oxidation by electron transfer: one- versus two-electron oxidation mechanism.Chemistry of Inflammation and DNA Damage: Biological Impact of Reactive Nitrogen Species
P2860
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P2860
DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
DNA lesions derived from the s ...... e by carbonate radical anions.
@ast
DNA lesions derived from the s ...... e by carbonate radical anions.
@en
type
label
DNA lesions derived from the s ...... e by carbonate radical anions.
@ast
DNA lesions derived from the s ...... e by carbonate radical anions.
@en
prefLabel
DNA lesions derived from the s ...... e by carbonate radical anions.
@ast
DNA lesions derived from the s ...... e by carbonate radical anions.
@en
P2093
P356
P1476
DNA lesions derived from the s ...... e by carbonate radical anions.
@en
P2093
Avrum Joffe
Nicholas E Geacintov
Vladimir Shafirovich
P304
P356
10.1021/TX034142T
P577
2003-12-01T00:00:00Z