Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts
about
Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complexSingle-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recordingReconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.Lifetimes and reaction pathways of guanine radical cations and neutral guanine radicals in an oligonucleotide in aqueous solutions.5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA ContextsComparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiationpH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair.Metal-mediated DNA damage and cell death: mechanisms, detection methods, and cellular consequences.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityFormation and processing of DNA damage substrates for the hNEIL enzymes.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairingComputational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin.8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.
P2860
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P2860
Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Characterization of 2'-deoxygu ...... d in the Fenton-like system Cu
@nl
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@ast
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@en
type
label
Characterization of 2'-deoxygu ...... d in the Fenton-like system Cu
@nl
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@ast
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@en
prefLabel
Characterization of 2'-deoxygu ...... d in the Fenton-like system Cu
@nl
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@ast
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@en
P2093
P2860
P356
P1476
Characterization of 2'-deoxygu ...... oligodeoxynucleotide contexts
@en
P2093
Aaron M Fleming
Cynthia J Burrows
James G Muller
P2860
P304
P356
10.1039/C1OB05112A
P577
2011-03-29T00:00:00Z