A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.
about
Metastasis: a question of life or deathMetastasis: a therapeutic target for cancer.M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancerStaged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachment.PTK6 regulates IGF-1-induced anchorage-independent survival.Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance.Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cellsAntiproliferative activity of novel imidazopyridine derivatives on castration-resistant human prostate cancer cellsAntimitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cellsBeyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitroApoptosis, autophagy, necroptosis, and cancer metastasisBcl-xL promotes metastasis independent of its anti-apoptotic activity.New insights of epithelial-mesenchymal transition in cancer metastasis.Integrative genomic approaches to understanding cancer.The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cellsFibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Metastasis: an early event in cancer progression.Anoikis and EMT: Lethal "Liaisons" during Cancer Progression.Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model.The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer.BCL-XL overexpression promotes tumor progression-associated properties.FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells.
P2860
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P2860
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A cytoskeleton-based functiona ...... but not primary tumor growth.
@ast
A cytoskeleton-based functiona ...... but not primary tumor growth.
@en
type
label
A cytoskeleton-based functiona ...... but not primary tumor growth.
@ast
A cytoskeleton-based functiona ...... but not primary tumor growth.
@en
altLabel
A cytoskeleton-based functiona ...... , but not primary tumor growth
@en
prefLabel
A cytoskeleton-based functiona ...... but not primary tumor growth.
@ast
A cytoskeleton-based functiona ...... but not primary tumor growth.
@en
P2093
P2860
P356
P1433
P1476
A cytoskeleton-based functiona ...... but not primary tumor growth.
@en
P2093
Alan G Ridgeway
Eugene Y Koh
Jan Pinkas
Joan S Brugge
Mauricio J Reginato
Montserrat Michelman
Philip Leder
Stuart S Martin
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207595
P407
P577
2004-06-01T00:00:00Z
P5875
P6179
1042667450