A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases.
about
High-throughput kinase assays with protein substrates using fluorescent polymer superquenchingCombining RNA interference and kinase inhibitors against cell signalling components involved in cancer.Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine KinaseA Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.High-throughput screening for kinase inhibitors.A robust screen for inhibitors and enhancers of phosphoinositide-3 kinase (PI3K) activities by ratiometric fluorescence superquenching.Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.Comparison of bioluminescent kinase assays using substrate depletion and product formation.Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screenIdentification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays.A structure-guided approach to creating covalent FGFR inhibitorsGroup I Paks as therapeutic targets in NF2-deficient meningioma.Zn(II)-Coordinated Quantum Dot-FRET Nanosensors for the Detection of Protein Kinase ActivityMeasuring and interpreting the selectivity of protein kinase inhibitorsMetal ion-mediated polymer superquenching for highly sensitive detection of kinase and phosphatase activitiesTransformation of in vitro tools for kinase profiling: keeping an eye over the off-target liabilities.Human kinome drug discovery and the emerging importance of atypical allosteric inhibitors.Developing assays for kinase drug discovery - where have the advances come from?Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies.Protein-quantum dot nanohybrids for bioanalytical applications.2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.A novel and selective inhibitor of PKC ζ potently inhibits human breast cancer metastasis in vitro and in mice.Fluorescent visualization of Src by using dasatinib-BODIPYOptimization of marine triterpene sipholenols as inhibitors of breast cancer migration and invasion.A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.Fullerene-based inhibitors of HIV-1 protease.Proteomic and functional analysis of the suite of Ysp proteins exported by the Ysa type III secretion system of Yersinia enterocolitica Biovar 1B.Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors.Benchmarking ligand-based virtual High-Throughput Screening with the PubChem database.Homogenous fluorescent assays for characterizing small-molecule activators of AMP-activated protein kinase (AMPK).Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets.A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches.Miniaturization of whole live cell-based GPCR assays using microdispensing and detection systems.A homogeneous, nonradioactive high-throughput fluorogenic protein phosphatase assay.A generic, homogenous method for measuring kinase and inhibitor activity via adenosine 5'-diphosphate accumulation.Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates.Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform.
P2860
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P2860
A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@ast
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@en
type
label
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@ast
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@en
prefLabel
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@ast
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@en
P2093
P1476
A FRET-based assay platform fo ...... tein kinases and phosphatases.
@en
P2093
Brian A Pollok
Brian D Hamman
Christina Lin
David Heidary
Jeffrey H Stack
Lew Makings
Steven M Rodems
Sundeep Shah
P356
10.1089/154065802761001266
P433
P577
2002-11-01T00:00:00Z