Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.
about
Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions.In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screeningA high-throughput TNP-ATP displacement assay for screening inhibitors of ATP-binding in bacterial histidine kinasesDevelopment and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in MelanomaTec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/TxkThe challenge of selecting protein kinase assays for lead discovery optimizationMeasuring and interpreting the selectivity of protein kinase inhibitorsITK inhibitors in inflammation and immune-mediated disorders.Transformation of in vitro tools for kinase profiling: keeping an eye over the off-target liabilities.Developing assays for kinase drug discovery - where have the advances come from?Targeting the unactivated conformations of protein kinases for small molecule drug discovery.The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach.Substrate independent ATPase activity may complicate high throughput screening.Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migrationMonitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.Evaluating PI3 kinase isoforms using Transcreener ADP assays.Update on in vitro cytotoxicity assays for drug development.Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform.Discovery and evaluation of triple inhibitors of VEGFR-2, TIE-2 and EphB4 as anti-angiogenic and anti-cancer agents.Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma.Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.A Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancer Cells and Inhibits Platelet Aggregation.
P2860
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P2860
Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年学术文章
@wuu
2006年学术文章
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2006年学术文章
@zh-hans
2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@ast
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@en
type
label
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@ast
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@en
prefLabel
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@ast
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@en
P2093
P2860
P356
P1476
Three mechanistically distinct ...... hensive set of ITK inhibitors.
@en
P2093
Anthony S Prokopowicz
Carol Ann Homon
George R Rogers
Jeffrey D Yingling
Jessi Wildeson Jones
John P Wolak
Maurice M Morelock
Mohammed A Kashem
Richard M Nelson
Roger J Snow
P2860
P356
10.1177/1087057106296047
P577
2006-12-08T00:00:00Z