Crystallins in water soluble-high molecular weight protein fractions and water insoluble protein fractions in aging and cataractous human lenses.
about
Role of αA-crystallin-derived αA66-80 peptide in guinea pig lens crystallin aggregation and insolubilization.αA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of α-crystallin and induces lens protein aggregationLens β-crystallins: the role of deamidation and related modifications in aging and cataract.Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formationAnti-chaperone betaA3/A1(102-117) peptide interacting sites in human alphaB-crystallinIsolation and characterization of betaA3-crystallin associated proteinase from alpha-crystallin fraction of human lenses.Age-related changes in the spatial distribution of human lens alpha-crystallin products by MALDI imaging mass spectrometry.Age-dependent deamidation of lifelong proteins in the human lens.Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labeling.Large-scale binding of α-crystallin to cell membranes of aged normal human lenses: a phenomenon that can be induced by mild thermal stressUbiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidationStructural and functional roles of deamidation of N146 and/or truncation of NH2- or COOH-termini in human αB-crystallin.The critical role of the central hydrophobic core (residues 71-77) of amyloid-forming αA66-80 peptide in α-crystallin aggregation: a systematic proline replacement study.A serine-type protease activity of human lens βA3-crystallin is responsible for its autodegradation.Understanding the α-crystallin cell membrane conjunction.Degradation of an old human protein: age-dependent cleavage of γS-crystallin generates a peptide that binds to cell membranesAge-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?The αA66-80 peptide interacts with soluble α-crystallin and induces its aggregation and precipitation: a contribution to age-related cataract formation.Identification of interaction sites between human betaA3- and alphaA/alphaB-crystallins by mammalian two-hybrid and fluorescence resonance energy transfer acceptor photobleaching methods.Effect of Mild Heating on Human Lens Epithelial Cells: A Possible Model of Lens Aging.Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts.Lens aging: effects of crystallins.N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin.The Human Eye Proteome Project: perspectives on an emerging proteome.Post-translationally modified human lens crystallin fragments show aggregation in vitro.The function of filensin and phakinin in lens transparency.Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates.Synergistic effects of metal ion and the pre-senile cataract-causing G98R alphaA-crystallin: self-aggregation propensities and chaperone activity.Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.Interaction of βA3-Crystallin with Deamidated Mutants of αA- and αB-Crystallins.Racemization at the Asp 58 residue in αA-crystallin from the lens of high myopic cataract patients.
P2860
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P2860
Crystallins in water soluble-high molecular weight protein fractions and water insoluble protein fractions in aging and cataractous human lenses.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystallins in water soluble-h ...... and cataractous human lenses.
@ast
Crystallins in water soluble-h ...... and cataractous human lenses.
@en
type
label
Crystallins in water soluble-h ...... and cataractous human lenses.
@ast
Crystallins in water soluble-h ...... and cataractous human lenses.
@en
prefLabel
Crystallins in water soluble-h ...... and cataractous human lenses.
@ast
Crystallins in water soluble-h ...... and cataractous human lenses.
@en
P2093
P1433
P1476
Crystallins in water soluble-h ...... and cataractous human lenses.
@en
P2093
Kiran Srivastava
Om P Srivastava
Shantis McCall
Veronica Harrington
P304
P577
2004-07-19T00:00:00Z