Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha.
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Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor CellsA diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.(-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen speciesPotent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilaneiMutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNAMechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin FCytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogsMechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.Nitric oxide inhibits topoisomerase II activity and induces resistance to topoisomerase II-poisons in human tumor cells.Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes.Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents.The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.Proteomic approaches in understanding action mechanisms of metal-based anticancer drugs.Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agentsCadmium is a catalytic inhibitor of DNA topoisomerase II.Reduction-sensitive amphiphilic triblock copolymers self-assemble into stimuli-responsive micelles for drug delivery.Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.De Novo DNA Synthesis in Aedes aegypti Midgut Cells as a Complementary Strategy to Limit Dengue Viral Replication.
P2860
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P2860
Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@ast
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@en
type
label
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@ast
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@en
prefLabel
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@ast
Biochemical and proteomics app ...... tion of topoisomerase IIalpha.
@en
P2093
P356
P1476
Biochemical and proteomics app ...... ition of topoisomerase IIalpha
@en
P2093
Angela Giorgianni
Brian B Hasinoff
Jack C Yalowich
Kenneth G Standing
Oleg V Krokhin
Shaohua Yang
Tejomoortula Sivaram
Werner Ens
P304
P356
10.1124/MOL.104.004416
P577
2004-12-15T00:00:00Z