Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.
about
PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targetingDeciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery processCrystal Structure of Yeast Rpn14, a Chaperone of the 19 S Regulatory Particle of the ProteasomeStructure of RCC1 chromatin factor bound to the nucleosome core particleRCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complexEthanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesIdentification of new Gβγ interaction sites in adenylyl cyclase 2.Pharmacology. Hitting the hot spots of cell signaling cascades.The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis.Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.Conformational flexibility and binding interactions of the G protein βγ heterodimer.Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunitsA chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.Rational design of a selective covalent modifier of G protein βγ subunits.NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.Direct-reversible binding of small molecules to G protein βγ subunits.Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.Inhibition of the ethanol-induced potentiation of α1 glycine receptor by a small peptide that interferes with Gβγ binding.State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimerSubunit dissociation and diffusion determine the subcellular localization of rod and cone transducinsG protein βγ subunits: central mediators of G protein-coupled receptor signaling.G protein betagamma subunits as targets for small molecule therapeutic development.Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma bindingNovel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsPrediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domainReversal of Ethanol-induced Intoxication by a Novel Modulator of Gβγ Protein Potentiation of the Glycine Receptor.Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides.Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.G protein βγ subunits directly interact with and activate phospholipase Cϵ.Interface Peptides
P2860
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P2860
Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural and molecular chara ...... G protein beta gamma subunits.
@ast
Structural and molecular chara ...... G protein beta gamma subunits.
@en
type
label
Structural and molecular chara ...... G protein beta gamma subunits.
@ast
Structural and molecular chara ...... G protein beta gamma subunits.
@en
prefLabel
Structural and molecular chara ...... G protein beta gamma subunits.
@ast
Structural and molecular chara ...... G protein beta gamma subunits.
@en
P2093
P356
P1433
P1476
Structural and molecular chara ...... G protein beta gamma subunits.
@en
P2093
Alan V Smrcka
Stephen R Sprang
Tabetha M Bonacci
P304
10593-10604
P356
10.1021/BI050655I
P407
P577
2005-08-01T00:00:00Z