Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
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Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitorsMolecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxenProtective effects of NSAIDs on the development of Alzheimer diseaseSelective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid.Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitratesCyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials.Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie.The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseGamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds.CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease.Novel γ-secretase modulators: a review of patents from 2008 to 2010.γ-Secretase inhibitors and modulators for Alzheimer's disease.Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.Development and mechanism of γ-secretase modulators for Alzheimer's disease.Modulating nitric oxide signaling in the CNS for Alzheimer's disease therapy.Novel flurbiprofen derivatives with improved brain delivery: synthesis, in vitro and in vivo evaluations.γ-Secretase Modulators and Inhibitors Induce Different Conformational Changes of Presenilin 1 Revealed by FLIM and FRET.New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels.Beyond benzyl grignards: facile generation of benzyl carbanions from styrenes.CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice.In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects.Structural and Chemical Biology of Presenilin Complexes.CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.Tacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease.
P2860
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P2860
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@ast
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@en
type
label
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@ast
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@en
prefLabel
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@ast
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@en
P2093
P356
P1476
Synthesis and biological activ ...... a-amyloid(1)(-)(42) secretion.
@en
P2093
Andrea Rizzi
Benedetta Riccardi
Bruno P Imbimbo
Carlo Parini
Chiara Bigogno
Elda Del Giudice
Fabrizio Facchinetti
Gino Villetti
Giulio Dondio
Ilaria Peretto
P304
P356
10.1021/JM0502541
P407
P577
2005-09-01T00:00:00Z