Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. - Wikidata - awgldk - TriplyDB

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.

http://www.wikidata.org/entity/Q33223993

about

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts DNA mismatch repair: molecular mechanism, cancer, and ageing The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways Rapid activation of ATR by ionizing radiation requires ATM and Mre11 ATR: an essential regulator of genome integrity Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Function of a conserved checkpoint recruitment domain in ATRIP proteins.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.DNA structure-specific priming of ATR activation by DNA-PKcs Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2 Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage.Checkpoint regulation of replication forks: global or local?Targeting the checkpoint kinase Chk1 in cancer therapy Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26.Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.Replication checkpoint: tuning and coordination of replication forks in s phase.A new in vitro system for activating the cell cycle checkpoint.

P2860

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P2860

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.

http://www.wikidata.org/entity/Q33223993

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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type

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Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

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P1433

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P1433

Journal of Biological Chemistry

P1476

Phosphorylation of Chk1 by ATM ...... coiled-coil domains of ATRIP.

@en

P2093

Akiko Kumagai

http://www.w3.org/2001/XMLSchema#string

Joon Lee

http://www.w3.org/2001/XMLSchema#string

Soo-Mi Kim

http://www.w3.org/2001/XMLSchema#string

William G Dunphy

http://www.w3.org/2001/XMLSchema#string

P2860

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

ATR and ATRIP: partners in checkpoint signaling

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

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38355-38364

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scholarly article

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10.1074/JBC.M508673200

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P433

46

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P478

280

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2005-09-25T00:00:00Z

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7578539

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16186122

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P921

phosphorylation