Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts
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Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesChk1 suppressed cell deathTreslin collaborates with TopBP1 in triggering the initiation of DNA replicationRepeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayHuman Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpointFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferationCharacterization of functional domains in human ClaspinTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsRegulatory motifs in Chk1The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationClaspin promotes normal replication fork rates in human cellsUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationMolecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phaseHuman claspin is required for replication checkpoint controlChecking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorRegulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activationNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathwayHuman claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresCheckpoint kinase 1 in DNA damage response and cell cycle regulationRoles of Chk1 in cell biology and cancer therapyPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRegulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345ETAA1 acts at stalled replication forks to maintain genome integrityATR: an essential regulator of genome integrityXenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMDetermination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegansA requirement for replication in activation of the ATR-dependent DNA damage checkpoint.Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakageCut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.Function of a conserved checkpoint recruitment domain in ATRIP proteins.
P2860
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P2860
Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts
description
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article
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artikull shkencor
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artículu científicu espublizáu en 2000
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im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2000
@uk
مقالة علمية (نشرت في أكتوبر 2000)
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ലേഖനം
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name
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@ast
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@en
type
label
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@ast
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@en
prefLabel
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@ast
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@en
P3181
P1433
P1476
Claspin, a Novel Protein Requi ...... sponse in Xenopus Egg Extracts
@en
P2093
Akiko Kumagai
William G. Dunphy
P304
P3181
P356
10.1016/S1097-2765(05)00092-4
P577
2000-10-01T00:00:00Z