Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. - Wikidata - awgldk - TriplyDB

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

http://www.wikidata.org/entity/Q33229596

about

Rescuing stalled or damaged replication forks Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.Evidence that a RecQ helicase slows senescence by resolving recombining telomeres The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.TOR signaling is a determinant of cell survival in response to DNA damage.Preventing replication fork collapse to maintain genome integrity Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae Assembly of Slx4 signaling complexes behind DNA replication forks ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.DNA replication stress is a determinant of chronological lifespan in budding yeast.Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast.Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss RecQ helicases: guardian angels of the DNA replication fork.Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei.The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z.Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.ATP-dependent chromatin remodeling factors tune S phase checkpoint activity Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation.Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2 The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1 JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast.Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.

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P2860

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

http://www.wikidata.org/entity/Q33229596

description

2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Replisome instability, fork co ...... e and RecQ helicase mutations.

@ast

Replisome instability, fork co ...... e and RecQ helicase mutations.

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type

label

Replisome instability, fork co ...... e and RecQ helicase mutations.

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Replisome instability, fork co ...... e and RecQ helicase mutations.

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prefLabel

Replisome instability, fork co ...... e and RecQ helicase mutations.

@ast

Replisome instability, fork co ...... e and RecQ helicase mutations.

@en

P1433

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Genes & Development

P1476

Replisome instability, fork co ...... e and RecQ helicase mutations.

@en

P2093

Jennifer A Cobb

http://www.w3.org/2001/XMLSchema#string

Lotte Bjergbaek

http://www.w3.org/2001/XMLSchema#string

Susan M Gasser

http://www.w3.org/2001/XMLSchema#string

Thomas Schleker

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Vanesa Rojas

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P2860

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

P304

3055-3069

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scholarly article

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10.1101/GAD.361805

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24

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P478

19

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José Antonio Tercero

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2005-12-01T00:00:00Z

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7413425

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16357221

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1315408

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