A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.
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Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastomaThe anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complexThe BTG2 protein is a general activator of mRNA deadenylationThe candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53The in vivo gene expression signature of oxidative stressNotch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinasesMechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapyAcquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypesThe BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 GenesMolecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesisGenomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitisThe LIM and SH3 domain protein family: structural proteins or signal transducers or both?Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific mannerExpression of B-cell translocation gene 2 is associated with favorable prognosis in hepatocellular carcinoma patients and sensitizes irradiation-induced hepatocellular carcinoma cell apoptosis in vitro and in nude miceComparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell linesUp-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarrayp53 regulates hematopoietic stem cell quiescence.Potential malignant transformation in the gastric mucosa of immunodeficient mice with persistent Mycoplasma penetrans infection.A resource for discovering specific and universal biomarkers for distributed stem cellsLoss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance.The dilution effect and the importance of selecting the right internal control genes for RT-qPCR: a paradigmatic approach in fetal sheep.A versatile modular vector system for rapid combinatorial mammalian geneticsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo.MiR-21: an environmental driver of malignant melanoma?Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis.SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.Control of alternative pre-mRNA splicing by Ca(++) signals.p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer.Divergent control of Cav-1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines.BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferationEndogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients.Insulin receptor-independent upregulation of cellular glucose uptakeOncogene-induced senescence: an essential role for Runx.B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells.BTG/TOB factors impact deadenylases.Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation.Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies.B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
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P2860
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A systematic search for downst ...... of Ras-induced transformation.
@ast
A systematic search for downst ...... of Ras-induced transformation.
@en
type
label
A systematic search for downst ...... of Ras-induced transformation.
@ast
A systematic search for downst ...... of Ras-induced transformation.
@en
prefLabel
A systematic search for downst ...... of Ras-induced transformation.
@ast
A systematic search for downst ...... of Ras-induced transformation.
@en
P2093
P2860
P356
P1433
P1476
A systematic search for downst ...... of Ras-induced transformation.
@en
P2093
Alexander D Boiko
Olga V Razorenova
Sarah Porteous
Vadim I Krivokrysenko
P2860
P304
P356
10.1101/GAD.1372606
P577
2006-01-01T00:00:00Z