The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.
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In vivo veritas: using yeast to probe the biological functions of G-quadruplexesStructure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solutionTelomerase as a Cancer Target. Development of New MoleculesTelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectA novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cellsHuman POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Mechanistic insight into ligand binding to G-quadruplex DNAFluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligandsChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expressionExploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.Structural insights into G-quadruplexes: towards new anticancer drugs.Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4"One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.G-quadruplex nucleic acids and human diseaseA small molecule inhibitor of Pot1 binding to telomeric DNA.Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiaeG-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteinsElevated levels of G-quadruplex formation in human stomach and liver cancer tissues.G-quadruplexes: from guanine gels to chemotherapeuticsThe nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNAHighly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compoundInduction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityGenomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae.Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stabilityFirst International Meeting on Quadruplex DNA.DNA secondary structures: stability and function of G-quadruplex structures.A hitchhiker's guide to G-quadruplex ligands.
P2860
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P2860
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.
description
2006 nî lūn-bûn
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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
The G-quadruplex ligand telome ...... from telomeres in human cells.
@ast
The G-quadruplex ligand telome ...... from telomeres in human cells.
@en
type
label
The G-quadruplex ligand telome ...... from telomeres in human cells.
@ast
The G-quadruplex ligand telome ...... from telomeres in human cells.
@en
prefLabel
The G-quadruplex ligand telome ...... from telomeres in human cells.
@ast
The G-quadruplex ligand telome ...... from telomeres in human cells.
@en
P2093
P1433
P1476
The G-quadruplex ligand telome ...... from telomeres in human cells.
@en
P2093
Alain Kolkes
Céline Douarre
Dennis Gomez
Hervé Kaplan
Jean-François Riou
Jérome Macadré
Kazuo Shin-ya
Marie-Françoise O'Donohue
Pascale Koebel
Thomas Wenner
P304
P356
10.1158/0008-5472.CAN-06-1581
P407
P577
2006-07-01T00:00:00Z