Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression
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Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNAFrom obesity to cancer: a review on proposed mechanisms.Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizersTargeting G-quadruplexes in gene promoters: a novel anticancer strategy?Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines.Making sense of G-quadruplex and i-motif functions in oncogene promoters.Targeting MYC Expression through G-Quadruplexes.Aptamer selection based on G4-forming promoter region.DNA acting like RNA.Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter regionDemonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer PopulationThe major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution.Sequence, stability, and structure of G-quadruplexes and their interactions with drugsInduction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityTargeting DNA G-quadruplex structures with peptide nucleic acids.DNA G-quadruplex and its potential as anticancer drug targetA dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoterTelomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.Emerging trends in G-quadruplex biology--role in epigenetic and evolutionary events.The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective TargetHelping Eve overcome ADAM: G-quadruplexes in the ADAM-15 promoter as new molecular targets for breast cancer therapeutics.Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.Transfecting RNA quadruplexes results in few transcriptome perturbationsRelevance of G-quadruplex structures to pharmacogenetics.Resolving the Ligand-Binding Specificity in c-MYC G-Quadruplex DNA: Absolute Binding Free Energy Calculations and SPR Experiment.Mixed guanine, adenine base quartets: possible roles of protons and metal ions in their stabilization.Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human.
P2860
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P2860
Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Molecular cloning of the human ...... repress PDGFR-beta expression
@ast
Molecular cloning of the human ...... repress PDGFR-beta expression
@en
type
label
Molecular cloning of the human ...... repress PDGFR-beta expression
@ast
Molecular cloning of the human ...... repress PDGFR-beta expression
@en
prefLabel
Molecular cloning of the human ...... repress PDGFR-beta expression
@ast
Molecular cloning of the human ...... repress PDGFR-beta expression
@en
P2093
P2860
P356
P1433
P1476
Molecular cloning of the human ...... repress PDGFR-beta expression
@en
P2093
Denise Tye
Jessica S Fortin
Laurence H Hurley
Mary Gleason-Guzman
Tracy A Brooks
P2860
P304
P356
10.1021/BI100330W
P407
P577
2010-05-01T00:00:00Z