Searching for new antimalarial therapeutics amongst known drugs. - Wikidata - awgldk - TriplyDB

Searching for new antimalarial therapeutics amongst known drugs.

Searching for new antimalarial therapeutics amongst known drugs.

http://www.wikidata.org/entity/Q33252500

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A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4 Thioridazine: resurrection as an antimicrobial agent?Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum Drug repurposing and human parasitic protozoan diseases Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation A new in vivo screening paradigm to accelerate antimalarial drug discovery Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products Chemical genetics of Plasmodium falciparum High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations Novel paradigms for drug discovery: computational multitarget screening Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.Inhibitors of tubulin assembly identified through screening a compound library.High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery.Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.Repositioning: the fast track to new anti-malarial medicines?Finding promiscuous old drugs for new uses.High content live cell imaging for the discovery of new antimalarial marine natural products A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.Target assessment for antiparasitic drug discovery.A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.Malaria biology and disease pathogenesis: insights for new treatments.Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors Chemical genomics for studying parasite gene function and interaction.Target validation: linking target and chemical properties to desired product profile Antiparasitic chemotherapy: from genomes to mechanisms.Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation Optimization of propafenone analogues as antimalarial leads Lead optimization of antimalarial propafenone analogues.Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery.Drug discovery and development for neglected parasitic diseases.Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

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P2860

Searching for new antimalarial therapeutics amongst known drugs.

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2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2006年の論文

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J.1747-0285.2006.00391.X

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Chemical Biology and Drug Design

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Searching for new antimalarial therapeutics amongst known drugs.

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Ally P Liou

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Anang A Shelat

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Jennifer L Weisman

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Joseph L DeRisi

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P2860

The economic and social burden of malaria

The potentiating action of tetrandrine in combination with chloroquine or qinghaosu against chloroquine-sensitive and resistant falciparum malaria

The three-dimensional structure of a Plasmodium falciparum cyclophilin in complex with the potent anti-malarial cyclosporin A

The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effe

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

Potent plasmodicidal activity of a heat-induced reformulation of deoxycholate-amphotericin B (Fungizone) against Plasmodium falciparum

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries.

Differential in vitro activities of ionophore compounds against Plasmodium falciparum and mammalian cells

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