Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. - Wikidata - awgldk - TriplyDB

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

http://www.wikidata.org/entity/Q36093316

about

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum Artemisinin-resistant malaria: research challenges, opportunities, and public health implications A molecular marker of artemisinin-resistant Plasmodium falciparum malaria Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia Computational and Practical Aspects of Drug Repositioning Drug resistance genomics of the antimalarial drug artemisinin Drug repurposing and human parasitic protozoan diseases Application of genomics to field investigations of malaria by the international centers of excellence for malaria research Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum PfCRT and its role in antimalarial drug resistance Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya High sensitivity of Giardia duodenalis to tetrahydrolipstatin (orlistat) in vitro Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance Drug resistance in eukaryotic microorganisms.High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo.Genome-wide polymorphisms and development of a microarray platform to detect genetic variations in Plasmodium yoelii.Exploring anti-malarial potential of FDA approved drugs: an in silico approach.Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.1H-NMR metabolite profiles of different strains of Plasmodium falciparum.Malaria biology and disease pathogenesis: insights for new treatments.A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Model system to define pharmacokinetic requirements for antimalarial drug efficacy.Chemical genomics for studying parasite gene function and interaction.Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite

P2860

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P2860

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

http://www.wikidata.org/entity/Q36093316

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Christopher P Austin

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Jing Yuan

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Ken Chih-Chien Cheng

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Sittiporn Pattaradilokrat

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Thomas E Wellems

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P2860

Qinghaosu (Artemisinin): The Price of Success

Artemisinin Resistance in Plasmodium falciparum Malaria

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

Thousands of chemical starting points for antimalarial lead identification

Clindamycin as an antimalarial drug: review of clinical trials.

Spiroindolones, a potent compound class for the treatment of malaria

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

Chemical genetics of Plasmodium falciparum

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724-729

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