Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
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Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications.The PIK3CA gene as a mutated target for cancer therapy.Microwave-assisted tandem transformation on an ionic-liquid support: efficient synthesis of pyrrolo/pyridobenzimidazolones and isoindolinone-fused benzimidazoles.The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.mTOR kinase: a possible pharmacological target in the management of chronic pain.Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapyThiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.Development and application of PI3K assays for novel drug discovery.Drugging the PI3 kinome: from chemical tools to drugs in the clinic.Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatmentA dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941Potential role of PI3K inhibitors in the treatment of breast cancer.Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorptionImidazo[1,2-a]pyrazine inhibitors of phosphoinositide 3-kinase alpha (PI3Kα): 3D-QSAR analysis utilizing the Hybrid Monte Carlo algorithm to refine receptor-ligand complexes for molecular alignment.New Multitarget Approaches in the War Against Glioblastoma: A Mini-PerspectiveA Convenient Synthesis of C-3-Aryloxymethyl Imidazo[1,2-a]Pyridine Derivatives
P2860
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P2860
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@ast
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@en
type
label
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@ast
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@en
prefLabel
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@ast
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@en
P2093
P1476
Synthesis and biological evalu ...... 3 kinase p110alpha inhibitors.
@en
P2093
Florence I Raynaud
Hiroyuki Kaizawa
Ken-Ichi Kawaguchi
Masahiko Hayakawa
Mayumi Yamano
Michael D Waterfield
Minoru Okada
Mitsuaki Ohta
Noriko Ishikawa
Peter Parker
P304
P356
10.1016/J.BMC.2006.09.047
P407
P50
P577
2006-10-16T00:00:00Z