A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
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Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsTumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in gliomaEGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastomaAkt and autophagy cooperate to promote survival of drug-resistant gliomaA critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapyChallenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment strategiesTargeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinasesCrystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors DesignThe susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposingFKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancerEGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growthPI3K pathway alterations in cancer: variations on a themeInhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerTargeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumorsConverging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell.Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.Targeting the cancer kinome through polypharmacology.Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapiesActivity of any class IA PI3K isoform can sustain cell proliferation and survival.Ribosome profiling reveals a cell-type-specific translational landscape in brain tumors.mTOR signaling in glioblastoma: lessons learned from bench to bedside.The proliferating role of insulin and insulin-like growth factors in cancer.PI3K: from the bench to the clinic and back.Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group.Phosphatidylinositol 3-kinase: the oncoprotein.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.PI3Kα inhibitors that inhibit metastasis.Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survivalTargeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.Glial progenitors as targets for transformation in glioma.Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block.Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies.Autophagy in brain tumors: a new target for therapeutic intervention.Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cellsPresent and Future of EGFR Inhibitors for Head and Neck Squamous Cell CancerProtein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells.Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.
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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@en
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@nl
type
label
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@en
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@nl
prefLabel
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@en
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@nl
P2093
P2860
P50
P1433
P1476
A dual phosphoinositide-3-kina ...... eceptor in PTEN-mutant glioma.
@en
P2093
Christine K Cheng
Christopher S Hackett
Kevan M Shokat
Qi-Wen Fan
P2860
P304
P356
10.1158/0008-5472.CAN-07-2154
P407
P577
2007-09-01T00:00:00Z