Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
about
SelectinsL-selectin activates the Ras pathway via the tyrosine kinase p56lckA role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesionRemodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic forceL-selectin from human, but not from mouse neutrophils binds directly to E-selectinAn activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flowP- and E-selectin use common sites for carbohydrate ligand recognition and cell adhesionTransmission of allostery through the lectin domain in selectin-mediated cell adhesion.Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin.Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocytosis in experimental meningitis in the rabbit.Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.Soluble L-selectin is present in human plasma at high levels and retains functional activity.Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrinsCell adhesion and focusing of inflammatory responses.Heparin inhibits leukocyte rolling in pial vessels and attenuates inflammatory changes in a rat model of experimental bacterial meningitis.Structural basis for selectin mechanochemistryCharacterization of an apparently conserved epitope in E- and P-selectin identified by dual-specific monoclonal antibodies.The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide.Anionic phospholipids bind to L-selectin (but not E-selectin) at a site distinct from the carbohydrate-binding site.The Ly-49 family: genes, proteins and recognition of class I MHC.Two sites on P-selectin (the lectin and epidermal growth factor-like domains) are involved in the adhesion of monocytes to thrombin-activated endothelial cells.T and IgA B lymphocytes of the pharyngeal and palatine tonsils: differential expression of adhesion molecules and chemokines.
P2860
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P2860
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
description
1991 nî lūn-bûn
@nan
1991 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@ast
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@en
type
label
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@ast
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@en
prefLabel
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@ast
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@en
P2093
P2860
P356
P1476
Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
@en
P2093
G S Kansas
L M Stoolman
O Spertini
T F Tedder
P2860
P304
P356
10.1083/JCB.114.2.351
P407
P577
1991-07-01T00:00:00Z