The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.
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Misfolded proteins partition between two distinct quality control compartmentsMitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation ProductsAlzheimer's Disease: Mechanism and Approach to Cell TherapyThree dimensions of the amyloid hypothesis: time, space and 'wingmen'Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: noninvasive measurement of the brain redox state by magnetic resonance imaging.Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disordersDelineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal.Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Aβ(1-42).Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease.Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease miceDi-tyrosine cross-link decreases the collisional cross-section of aβ peptide dimers and trimers in the gas phase: an ion mobility study.Exploring the biology of lipid peroxidation-derived protein carbonylation.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseThe role of environmental exposures in neurodegeneration and neurodegenerative diseases.BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson diseaseNeuronal and vascular oxidative stress in Alzheimer's disease.Interactions of glutathione transferases with 4-hydroxynonenal.The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferasesTransglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiationDiaryl hydrazones as multifunctional inhibitors of amyloid self-assembly.Interaction of aldehydes derived from lipid peroxidation and membrane proteinsHydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway.Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicityThe link between intraneuronal N-truncated amyloid-β peptide and oxidatively modified lipids in idiopathic autism and dup(15q11.2-q13)/autism.Nitric Oxide: Exploring the Contextual Link with Alzheimer's DiseaseMitochondrial dysfunction and oxidative stress in aging and cancer.Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Dietary lipids and their oxidized products in Alzheimer's disease.4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studiesTransforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs.Overlapped metabolic and therapeutic links between Alzheimer and diabetes.Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells.Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity.How can we target oxidative stress in the treatment of neurodegenerative diseases?
P2860
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P2860
The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The oxidative stress metabolit ...... zheimer protofibril formation.
@ast
The oxidative stress metabolit ...... zheimer protofibril formation.
@en
type
label
The oxidative stress metabolit ...... zheimer protofibril formation.
@ast
The oxidative stress metabolit ...... zheimer protofibril formation.
@en
prefLabel
The oxidative stress metabolit ...... zheimer protofibril formation.
@ast
The oxidative stress metabolit ...... zheimer protofibril formation.
@en
P2860
P356
P1433
P1476
The oxidative stress metabolit ...... zheimer protofibril formation.
@en
P2093
Jan Bieschke
Sarah J Siegel
P2860
P304
P356
10.1021/BI061853S
P407
P577
2007-02-01T00:00:00Z