about
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenicEvaluating beta-turn mimics as beta-sheet folding nucleatorsBenzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of actionALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilizationBinding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher DiseaseStructural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in ProteinsTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeFluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learnAβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic lossThe oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Prevention of transthyretin amyloid disease by changing protein misfolding energetics.Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity.Targeting protein aggregation for the treatment of degenerative diseasesBackbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.N-glycosylation of enhanced aromatic sequons to increase glycoprotein stabilitySmall molecule oxidation products trigger disease-associated protein misfolding.Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic SequonProtein energetics in maturation of the early secretory pathway.Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr ResidueThe Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicityMetabolite-initiated protein misfolding may trigger Alzheimer's disease.The proteostasis boundary in misfolding diseases of membrane traffic.Quantification of transthyretin kinetic stability in human plasma using subunit exchange.The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.Diversity in the origins of proteostasis networks--a driver for protein function in evolutionSmall molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.Current and future treatment of amyloid diseases.N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation.Ligand-promoted protein folding by biased kinetic partitioning.Influence of the N-terminal domain on the aggregation properties of the prion protein.Amyloid-β forms fibrils by nucleated conformational conversion of oligomersCorrection to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics.Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns.Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Evan T Powers
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Evan T Powers
@en
Evan T Powers
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Evan T Powers
@nl
Evan T Powers
@sl
type
label
Evan T Powers
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Evan T Powers
@en
Evan T Powers
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Evan T Powers
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Evan T Powers
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prefLabel
Evan T Powers
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Evan T Powers
@en
Evan T Powers
@es
Evan T Powers
@nl
Evan T Powers
@sl
P106
P108
P21
P31
P496
0000-0001-8185-8487