Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function.
about
Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in ratsIn vitro and in vivo modifications of recombinant and human IgG antibodiesAcceptable changes in quality attributes of glycosylated biopharmaceuticalsHuman IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activationConsistency of quality attributes for the glycosylated monoclonal antibody Humira® (adalimumab).Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approachesAnalysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2007-2008.Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies.Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells.Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein.Should charge variants of monoclonal antibody therapeutics be considered critical quality attributes?Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry.Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry.Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media.Evaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept.Pharmacokinetic Comparability of a Biosimilar Trastuzumab Anticipated from Its Physicochemical and Biological Characterization.Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture ComponentsAnalysis of reduced monoclonal antibodies using size exclusion chromatography coupled with mass spectrometry.C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo.Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact.Analytical comparability study of recombinant monoclonal antibody therapeutics.
P2860
Q24619854-1C400895-B4C5-4627-9FA4-8BC923D8BAD2Q26859713-AF6F2898-F1DA-4EDD-AE9A-123B8BB020DAQ28235143-9FD01B59-397E-4461-B69E-A7E48D4E91E4Q30360964-73313B20-F561-4E07-8ACD-D5F57EFD7ED9Q30377369-6F9D644F-3665-4256-8218-FFB3F71B1DCDQ33641917-97A1B942-9153-4261-AF25-81675FF11216Q33995843-656AE30D-E902-4B1F-A3E1-7DCBE9C98975Q36402682-DF103BC3-B690-4993-8640-719656330F56Q37692235-BB97FDCA-C245-469B-BC48-0DCB711FDFF2Q37999739-5B6508C8-98B8-4C42-AE08-3C27CBA51A83Q38246996-B625DB7E-5CF6-4C31-8674-3318A123A6A9Q38740314-7C50BC73-E4C6-436C-BBCE-F456261986C8Q38759336-DCF8F54F-2CAB-4965-8F55-B162FD6FD411Q38785280-35D532A5-247D-4502-AFBC-54DBF23250EAQ38812885-365C1D93-2022-4AC3-BB10-0D43A9771BA6Q39230268-F63BC489-FF53-441B-9A3C-A43F0E21EBA6Q39369733-49E38B46-A7CA-4B1C-8005-48EFD36A0738Q39720491-A9ADE561-E705-4BC9-9157-BD31A64C01F8Q42000964-4340ED7F-04DD-4C86-A970-6427C9E7D270Q42363063-B8A2E32B-DC00-411B-A322-BF9BD399A3DFQ43270084-744525F5-3CF9-4D84-8D34-0AB983B11E2EQ44559709-CC52CAD5-AB53-44E3-9136-FDF927E40A09Q50237001-8C80E523-3480-43BC-8B14-A15B3F74414BQ52669512-5907A185-8DD0-42A8-A9E2-F472E34BE2A4
P2860
Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Analysis of lysine clipping of ...... Fc-mediated effector function.
@ast
Analysis of lysine clipping of ...... Fc-mediated effector function.
@en
Analysis of lysine clipping of ...... Fc-mediated effector function.
@nl
type
label
Analysis of lysine clipping of ...... Fc-mediated effector function.
@ast
Analysis of lysine clipping of ...... Fc-mediated effector function.
@en
Analysis of lysine clipping of ...... Fc-mediated effector function.
@nl
prefLabel
Analysis of lysine clipping of ...... Fc-mediated effector function.
@ast
Analysis of lysine clipping of ...... Fc-mediated effector function.
@en
Analysis of lysine clipping of ...... Fc-mediated effector function.
@nl
P2093
P1476
Analysis of lysine clipping of ...... Fc-mediated effector function.
@en
P2093
Andreas Nechansky
Andreas Rizzi
Bernhard Antes
Manuela Kainer
Markus Fido
Oliver Szolar
Ralf Kircheis
Susi Wiederkum
P304
P356
10.1016/J.JCHROMB.2007.01.024
P50
P577
2007-01-26T00:00:00Z