Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss - Wikidata - awgldk - TriplyDB

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

http://www.wikidata.org/entity/Q33280200

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Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair Cellular and molecular biology of aging endothelial cells Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice Mitochondrial biogenesis drives a vicious cycle of metabolic insufficiency and mitochondrial DNA deletion mutation accumulation in aged rat skeletal muscle fibers Do mtDNA deletions drive premature aging in mtDNA mutator mice?Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Mitochondria Initiate and Regulate Sarcopenia Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle.Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence?The road to rack and ruin: selecting deleterious mitochondrial DNA variants Sarcopenia: etiology, clinical consequences, intervention, and assessment.Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging.Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.The role of PGC-1 coactivators in aging skeletal muscle and heart.Does mtDNA nucleoid organization impact aging?Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury.Mitochondrial DNA alterations and reduced mitochondrial function in aging Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'.Mitochondrial oxidative stress and mammalian healthspan.Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints.Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice.Mitochondrial-nuclear epistasis: implications for human aging and longevity.The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria.Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death.Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle.Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities.

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Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

http://www.wikidata.org/entity/Q33280200

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2007 nî lūn-bûn

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The Journals of Gerontology

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Accumulation of mitochondrial ...... usal role in muscle fiber loss

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Allen Herbst

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Debbie McKenzie

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Entela Bua

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Jeong W Pak

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Judd M Aiken

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Marwa Bassiouni

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P2860

Premature ageing in mice expressing defective mitochondrial DNA polymerase

The biologic clock: the mitochondria?

Mitochondrial diseases in man and mouse

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection.

Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys.

The genetics and pathology of oxidative phosphorylation.

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome

A proposed refinement of the mitochondrial free radical theory of aging.

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235-245

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3

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62

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51374687

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17389720

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mitochondrial DNA

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2846622

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