Positive aspects of negative design: simultaneous selection of specificity and interaction stability.
about
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonistsIn situ click chemistry: from small molecule discovery to synthetic antibodiesDesigning specific protein-protein interactions using computation, experimental library screening, or integrated methodsTruncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1Tradeoff between stability and multispecificity in the design of promiscuous proteins.Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate.Truncation, randomization, and selection: generation of a reduced length c-Jun antagonist that retains high interaction stabilityProtein binding specificity versus promiscuity.Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization.Structural specificity in coiled-coil interactions.Design of protein-interaction specificity gives selective bZIP-binding peptides.Characterization and inhibition of AF10-mediated interaction.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Deriving Heterospecific Self-Assembling Protein-Protein Interactions Using a Computational Interactome Screen.Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention.Functional and Structural Roles of Coiled Coils.Photocontrol of coiled-coil proteins in living cells.Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1Increasing the affinity of selective bZIP-binding peptides through surface residue redesign.Improved stability of the Jun-Fos Activator Protein-1 coiled coil motif: A stopped-flow circular dichroism kinetic analysis.Supramolecular replication of peptide and DNA patterned arrays
P2860
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P2860
Positive aspects of negative design: simultaneous selection of specificity and interaction stability.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Positive aspects of negative d ...... ity and interaction stability.
@ast
Positive aspects of negative d ...... ity and interaction stability.
@en
Positive aspects of negative d ...... ity and interaction stability.
@nl
type
label
Positive aspects of negative d ...... ity and interaction stability.
@ast
Positive aspects of negative d ...... ity and interaction stability.
@en
Positive aspects of negative d ...... ity and interaction stability.
@nl
prefLabel
Positive aspects of negative d ...... ity and interaction stability.
@ast
Positive aspects of negative d ...... ity and interaction stability.
@en
Positive aspects of negative d ...... ity and interaction stability.
@nl
P356
P1433
P1476
Positive aspects of negative d ...... ity and interaction stability.
@en
P2093
Katja M Arndt
Kristian M Müller
P304
P356
10.1021/BI602506P
P407
P577
2007-04-03T00:00:00Z