Tradeoff between stability and multispecificity in the design of promiscuous proteins.
about
Beauty is in the eye of the beholder: proteins can recognize binding sites of homologous proteins in more than one wayAffinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPsDesigning specific protein-protein interactions using computation, experimental library screening, or integrated methodsInferring the microscopic surface energy of protein-protein interfaces from mutation data.A generic program for multistate protein design.Protein binding specificity versus promiscuity.Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention.Lessons in Protein Design from Combined Evolution and Conformational Dynamics.Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M β-lactamases.Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces.Searching for the Pareto frontier in multi-objective protein design.Increasing the affinity of selective bZIP-binding peptides through surface residue redesign.BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases.Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.Diversity in peptide recognition by the SH2 domain of SH2B1.Rigid-body motions of interacting proteins dominate multispecific binding of ubiquitin in a shape-dependent manner.Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy.
P2860
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P2860
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@ast
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@en
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@nl
type
label
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@ast
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@en
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@nl
prefLabel
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@ast
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@en
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@nl
P2860
P1476
Tradeoff between stability and multispecificity in the design of promiscuous proteins.
@en
P2093
Julia M Shifman
P2860
P304
P356
10.1371/JOURNAL.PCBI.1000627
P577
2009-12-24T00:00:00Z