Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. - Wikidata - awgldk - TriplyDB

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

http://www.wikidata.org/entity/Q33283342

about

Feedback between p21 and reactive oxygen production is necessary for cell senescence Oxidative stress, mitochondrial dysfunction, and aging Therapeutic Targeting of Telomerase Cellular Senescence as the Causal Nexus of Aging Markers of cellular senescence. Telomere shortening as a marker of cellular senescence The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease Axis of ageing: telomeres, p53 and mitochondria Role of advanced glycation end products in cellular signaling Oxidative stress and pulmonary fibrosis Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae The effect of environmental chemicals on the tumor microenvironment Causes of genome instability: the effect of low dose chemical exposures in modern society Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations Ambient oxygen promotes tumorigenesis Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations Lung cancer incidence decreases with elevation: evidence for oxygen as an inhaled carcinogen The asymmetry of telomere replication contributes to replicative senescence heterogeneity.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.Mitochondria, endothelial cell function, and vascular diseases.Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in Cardiac Cell Senescence and Redox Signaling.KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.Gene regulatory changes in yeast during life extension by nutrient limitation Cellular senescence and protein degradation: breaking down cancer mTOR Signaling from Cellular Senescence to Organismal Aging Autophagy impairment induces premature senescence in primary human fibroblasts.Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state.Microenvironmental regulation of telomerase isoforms in human embryonic stem cells Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.

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P2860

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

http://www.wikidata.org/entity/Q33283342

description

2007 nî lūn-bûn

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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年论文

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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type

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Mitochondrial dysfunction acco ...... telomere-dependent senescence.

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Glyn Nelson

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Graham Harold

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Heiko Peters

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Ilka Wappler

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João F Passos

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Karin Schaeuble

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Mark A Birch-Machin

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Shaheda Ahmed

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Torsten Richter

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P2860

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

Accelerated telomere shortening in response to life stress

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Aging: a theory based on free radical and radiation chemistry

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Superoxide activates mitochondrial uncoupling proteins

The biologic clock: the mitochondria?

Vascular respiratory uncoupling increases blood pressure and atherosclerosis

The serial cultivation of human diploid cell strains

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e110

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