Scaffold composition and biological relevance of screening libraries.
about
Global phenotypic screening for antimalarialsIdentifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screenSynthesis and Evaluation of a 2,11-Cembranoid-Inspired LibraryChemical genetics of Plasmodium falciparumA ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data.Data-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.A road less traveled by: exploring a decade of Ellman chemistry.Synthesis of unprecedented scaffold diversity.Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).Probing chemical space with alkaloid-inspired libraries.Diversity-oriented synthesis of macrocyclic peptidomimetics.Synthesis of novel molecular probes inspired by harringtonolide.Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks.Towards the systematic exploration of chemical space.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?Structural diversity and potency range distribution of scaffolds from compounds active against current pharmaceutical targets.De novo branching cascades for structural and functional diversity in small molecules.Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1).Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Efficient access to sp3-rich tricyclic amine scaffolds through Diels-Alder reactions of azide-containing silyloxydienes.A dual-targeting approach to inhibit Brucella abortus replication in human cells.Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures.Determining target engagement in living systemsFragment informatics and computational fragment-based drug design: an overview and update.A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.High-throughput and in silico screenings in drug discovery.Rule-Based Classification of Chemical Structures by Scaffold.Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery.Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90.Pharmacological use of a novel scaffold, anomeric N,N-diarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence.2D depiction of fragment hierarchies.Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocksVinylation of nitro-substituted indoles, quinolinones, and anilides with grignard reagents.
P2860
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P2860
Scaffold composition and biological relevance of screening libraries.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Scaffold composition and biological relevance of screening libraries.
@ast
Scaffold composition and biological relevance of screening libraries.
@en
type
label
Scaffold composition and biological relevance of screening libraries.
@ast
Scaffold composition and biological relevance of screening libraries.
@en
prefLabel
Scaffold composition and biological relevance of screening libraries.
@ast
Scaffold composition and biological relevance of screening libraries.
@en
P356
P1476
Scaffold composition and biological relevance of screening libraries
@en
P2093
Anang A Shelat
P2860
P2888
P304
P356
10.1038/NCHEMBIO0807-442
P50
P577
2007-08-01T00:00:00Z