Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
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Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence DisorderCHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradationDevelopment and application of a DNA microarray-based yeast two-hybrid systemAtaxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationBoat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1Gene, Stem Cell, and Alternative Therapies for SCA 1Developmental Dynamics of Rett SyndromeCell biology of spinocerebellar ataxiaBeyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1The unstable repeats--three evolving faces of neurological diseasePolyglutamine neurodegeneration: expanded glutamines enhance native functionsNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingThe structure of the AXH domain of spinocerebellar ataxin-1Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua14-3-3 protein targets misfolded chaperone-associated proteins to aggresomesMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive ReviewChibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activityThe DISC locus in psychiatric illnessModulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosisLithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factorsThe insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMAPrediction of protein-destabilizing polymorphisms by manual curation with protein structure.CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.A meta-analysis of multiple matched copy number and transcriptomics data sets for inferring gene regulatory relationships.Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Oligonucleotide-based strategies to combat polyglutamine diseases.Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in DrosophilaDrosophila melanogaster in the study of human neurodegeneration.Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons.RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1Network organization of the huntingtin proteomic interactome in mammalian brain.
P2860
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P2860
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@ast
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@en
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@nl
type
label
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@ast
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@en
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@nl
prefLabel
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@ast
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@en
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@nl
P2093
P50
P1433
P1476
Interaction of Akt-phosphoryla ...... spinocerebellar ataxia type 1.
@en
P2093
Alastair Aitken
Efthimios M C Skoulakis
Hung-Kai Chen
Juan Botas
Michael D Kaytor
Michael H Fernandez
Pedro Fernandez-Funez
Yung C Lam
P304
P356
10.1016/S0092-8674(03)00349-0
P407
P577
2003-05-01T00:00:00Z