Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors
about
A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhADesign and Synthesis of Aryl Ether Inhibitors of theBacillus AnthracisEnoyl-ACP ReductaseSlow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo ActivityA Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall PermeabilityTime-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo EfficacySynthesis and structural activity relationship study of antitubercular carboxamidesA trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosisSlow-Onset Inhibition of Mycobacterium tuberculosis InhA: Revealing Molecular Determinants of Residence Time by MD SimulationsDiarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosisSubstituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.Using a Label Free Quantitative Proteomics Approach to Identify Changes in Protein Abundance in Multidrug-Resistant Mycobacterium tuberculosis.Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response.Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemiaSAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.Recent advances in antituberculous drug development and novel drug targets.Therapeutic potential of FtsZ inhibition: a patent perspective.Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors as potential antituberculotics: development in the past decade.Recent Advances and Structural Features of Enoyl-ACP Reductase Inhibitors of Mycobacterium tuberculosis.Key Structures and Interactions for Binding of Mycobacterium tuberculosis Protein Kinase B Inhibitors from Molecular Dynamics Simulation.New structural classes of antituberculosis agents.Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis.Elucidating the structural basis of diphenyl ether derivatives as highly potent enoyl-ACP reductase inhibitors through molecular dynamics simulations and 3D-QSAR study.Identification of membrane-associated proteins with pathogenic potential expressed by Corynebacterium pseudotuberculosis grown in animal serum.
P2860
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P2860
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@ast
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@en
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors.
@nl
type
label
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@ast
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@en
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors.
@nl
prefLabel
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@ast
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@en
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors.
@nl
P2093
P2860
P921
P356
P1476
Targeting fatty acid biosynthe ...... high-affinity InhA inhibitors
@en
P2093
Anita G Amin
Anne Lenaerts
Christopher W amEnde
Darragh Heaslip
Delphi Chatterjee
Melissa E Boyne
Todd J Sullivan
Veronica Gruppo
P2860
P304
P356
10.1128/AAC.00383-07
P407
P577
2007-07-30T00:00:00Z