Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. - Wikidata - awgldk - TriplyDB

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

http://www.wikidata.org/entity/Q33761632

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A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis [Better search strategies, hopeful candidates. The search for new antimycobacterial drugs].Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor.SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly.Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis.Drug discovery targeting cell division proteins, microtubules and FtsZ.Antibiotics and bacterial resistance in the 21st century.Benzimidazole-based antibacterial agents against Francisella tularensis.A novel quinoline derivative that inhibits mycobacterial FtsZ.A novel multi-component reaction to imidazo[4,5-g]-quinazolines.Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.BT-benzo-29 inhibits bacterial cell proliferation by perturbing FtsZ assembly.Quantitative structure-activity relationship of molecules constituent of different essential oils with antimycobacterial activity against Mycobacterium tuberculosis and Mycobacterium bovis.Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis.Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.Antituberculosis drug research: a critical overview.The development of FtsZ inhibitors as potential antibacterial agents.Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.Recent Development of Benzimidazole-Containing Antibacterial Agents.Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.Identification of agents targeting FtsZ assembly.New structural classes of antituberculosis agents.Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates.Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis.Design and Synthesis of Some Novel Fluorobenzimidazoles Substituted with Structural Motifs Present in Physiologically Active Natural Products for Antitubercular Activity.

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P2860

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

http://www.wikidata.org/entity/Q33761632

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Novel trisubstituted benzimida ...... lass of antitubercular agents.

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Journal of Medicinal Chemistry

P1476

Novel trisubstituted benzimida ...... lass of antitubercular agents.

@en

P2093

Bela Ruzsicska

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Divya Awasthi

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Ilaria Zanardi

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Kunal Kumar

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Seung-Yub Lee

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Susan Knudson

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P2860

FtsZ ring structure associated with division in Escherichia coli

Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa

Slow polymerization of Mycobacterium tuberculosis FtsZ

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

Cytokinesis in bacteria

Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors

Analysis of FtsZ assembly by light scattering and determination of the role of divalent metal cations.

Issues facing TB control (7). Multiple drug-resistant tuberculosis.

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity.

Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives.

P304

374-381

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10.1021/JM1012006

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1

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54

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Richard Slayden

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2010-12-02T00:00:00Z

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49652978

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21126020

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3071426

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