A randomized library approach to identifying functional lox site domains for the Cre recombinase.
about
Genome-scale engineering for systems and synthetic biologyMutants of Cre recombinase with improved accuracyReplacing the wild type loxP site in BACs from the public domain with lox66 using a lox66 transposon.Generating libraries of iTol2-end insertions at BAC ends using loxP and lox511 Tn10 transposonsRedesign of the monomer-monomer interface of Cre recombinase yields an obligate heterotetrameric complex.Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site.Identifying Distal cis-acting Gene-Regulatory Sequences by Expressing BACs Functionalized with loxP-Tn10 Transposons in Zebrafish.Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons.Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA.The tyrosine recombinase MrpA and its target sequence: a mutational analysis of the recombination site mrpS resulting in a new left element/right element (LE/RE) deletion system.Site-specific integration of transgene targeting an endogenous lox-like site in early mouse embryos.A new site-specific recombinase-mediated system for targeted multiple genomic deletions employing chimeric loxP and mrpS sites.Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods.Engineering altered protein-DNA recognition specificity.
P2860
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P2860
A randomized library approach to identifying functional lox site domains for the Cre recombinase.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A randomized library approach ...... mains for the Cre recombinase.
@ast
A randomized library approach ...... mains for the Cre recombinase.
@en
A randomized library approach ...... mains for the Cre recombinase.
@nl
type
label
A randomized library approach ...... mains for the Cre recombinase.
@ast
A randomized library approach ...... mains for the Cre recombinase.
@en
A randomized library approach ...... mains for the Cre recombinase.
@nl
prefLabel
A randomized library approach ...... mains for the Cre recombinase.
@ast
A randomized library approach ...... mains for the Cre recombinase.
@en
A randomized library approach ...... mains for the Cre recombinase.
@nl
P2860
P356
P1476
A randomized library approach ...... omains for the Cre recombinase
@en
P2093
Jamie Sheren
Stephen J Langer
P2860
P304
P356
10.1093/NAR/GKM604
P407
P577
2007-08-15T00:00:00Z