SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
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Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionMetabolism, longevity and epigeneticsModulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-RegulationMammalian sirtuins: biological insights and disease relevanceSIRT1 is essential for normal cognitive function and synaptic plasticityOpposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activityEffects of Rhein lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cellsCross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.How does SIRT1 affect metabolism, senescence and cancer?p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.Adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation.Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.Polyphenols and aging.Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells.The impact of acetylation and deacetylation on the p53 pathway.Chromatin remodeling, DNA damage repair and aging.SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence.Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.miR-22 represses cancer progression by inducing cellular senescenceMitochondrial effectors of cellular senescence: beyond the free radical theory of agingSIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice.FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway.The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.The sirtuins in the pathogenesis of cancer.Alteration of Aging-Dependent MicroRNAs in Idiopathic Pulmonary Fibrosis.Sirtuins of parasitic protozoa: in search of function(s).Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature.Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts.Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells.
P2860
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P2860
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@ast
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@en
SIRT1 overexpression antagoniz ...... in human diploid fibroblasts.
@nl
type
label
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@ast
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@en
SIRT1 overexpression antagoniz ...... in human diploid fibroblasts.
@nl
prefLabel
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@ast
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@en
SIRT1 overexpression antagoniz ...... in human diploid fibroblasts.
@nl
P2093
P2860
P1433
P1476
SIRT1 overexpression antagoniz ...... g in human diploid fibroblasts
@en
P2093
Jing Huang
Tanjun Tong
Zongyu Zhang
P2860
P356
10.1371/JOURNAL.PONE.0001710
P407
P577
2008-03-05T00:00:00Z