A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.
about
Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsFormation of lipofuscin-like material in the RPE Cell by different components of rod outer segments.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsEffect of short-term oral valproic Acid on vision and visual field in retinitis pigmentosa.Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Phenylalanine hydroxylase misfolding and pharmacological chaperones.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsImpact of Subunit Composition on the Uptake of α-Crystallin by Lens and RetinaA High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degenerationExplant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Efficacy of valproic acid for retinitis pigmentosa patients: a pilot studyDocking and chemoinformatic screens for new ligands and targets.Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.Misfolded proteins and retinal dystrophies.Molecular genetics of retinal degeneration: A Drosophila perspective.Gene therapy in animal models of autosomal dominant retinitis pigmentosaLong-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid.Investigational and experimental GnRH analogs and associated neurotransmitters.Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa.Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa.Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.Ligand channel in pharmacologically stabilized rhodopsin.A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors
P2860
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P2860
A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A high-throughput screening me ...... erones of misfolded rhodopsin.
@ast
A high-throughput screening me ...... erones of misfolded rhodopsin.
@en
A high-throughput screening me ...... erones of misfolded rhodopsin.
@nl
type
label
A high-throughput screening me ...... erones of misfolded rhodopsin.
@ast
A high-throughput screening me ...... erones of misfolded rhodopsin.
@en
A high-throughput screening me ...... erones of misfolded rhodopsin.
@nl
prefLabel
A high-throughput screening me ...... erones of misfolded rhodopsin.
@ast
A high-throughput screening me ...... erones of misfolded rhodopsin.
@en
A high-throughput screening me ...... erones of misfolded rhodopsin.
@nl
P2093
P921
P356
P1476
A high-throughput screening me ...... erones of misfolded rhodopsin.
@en
P2093
David A Ostrov
J Hugh McDowell
Shalesh Kaushal
Syed M Noorwez
P304
P356
10.1167/IOVS.07-1539
P407
P577
2008-03-31T00:00:00Z