Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.
about
Pharmacological chaperoning: a primer on mechanism and pharmacologyEmerging novel concept of chaperone therapies for protein misfolding diseasesChaperoning G protein-coupled receptors: from cell biology to therapeuticsRescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Gene augmentation for adRP mutations in RHO.ER stress in retinal degeneration in S334ter Rho rats.AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa.Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies.IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsinM-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant cultureRescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.Protein misfolding and retinal degenerationEndoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins and mutant P23H rhodopsin in photoreceptor cells.The cell stress machinery and retinal degeneration.The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.BiP prevents rod opsin aggregation.Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking.Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa.The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Pharmacological Chaperones: Beyond Conformational Disorders.
P2860
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P2860
Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@en
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@nl
type
label
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@en
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@nl
prefLabel
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@en
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@nl
P2093
P2860
P356
P1476
Calnexin improves the folding ...... ical chaperone 11-cis-retinal.
@en
P2093
Reddy Ranjith K Sama
Shalesh Kaushal
Syed M Noorwez
P2860
P304
33333-33342
P356
10.1074/JBC.M109.043364
P407
P577
2009-10-02T00:00:00Z