In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. - Wikidata - awgldk - TriplyDB

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

http://www.wikidata.org/entity/Q33327474

about

An optogenetic toolbox designed for primates Directed evolution of adeno-associated virus to an infectious respiratory virus Analysis of conditional heterozygous STXBP1 mutations in human neurons Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission.Genome-editing Technologies for Gene and Cell Therapy Adeno-associated Virus as a Mammalian DNA Vector Recombination in eukaryotic single stranded DNA viruses Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion Electron microscopy analysis of a disaccharide analog complex reveals receptor interactions of adeno-associated virus Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5 Å Resolution E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution Targeting cells with single vectors using multiple-feature Boolean logic Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.Five colour variants of bright luminescent protein for real-time multicolour bioimaging.DNA shuffling of adeno-associated virus yields functionally diverse viral progeny A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection.Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.Directed evolution of adeno-associated virus for glioma cell transduction Molecular evolution of adeno-associated virus for enhanced glial gene delivery.Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library.Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy.The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide.AAV's anatomy: roadmap for optimizing vectors for translational success Systemic gene delivery to the central nervous system using Adeno-associated virus.Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.Deletion of the B-B' and C-C' regions of inverted terminal repeats reduces rAAV productivity but increases transgene expression A NEW RECOMBINANT ADENO-ASSOCIATED VIRUS (AAV)-BASED RANDOM PEPTIDE DISPLAY LIBRARY SYSTEM: INFECTION-DEFECTIVE AAV1.9-3 AS A NOVEL DETARGETED PLATFORM FOR VECTOR EVOLUTION.Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo.Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors.Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity.Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.Directed evolution of novel adeno-associated viruses for therapeutic gene delivery.

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P2860

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

http://www.wikidata.org/entity/Q33327474

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年论文

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In vitro and in vivo gene ther ...... g of adeno-associated viruses.

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Journal of Virology

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In vitro and in vivo gene ther ...... g of adeno-associated viruses.

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P2093

Bassel Akache

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Dirk Grimm

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Joyce S Lee

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Lora Wang

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Mark A Kay

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Theresa A Storm

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Tushar Desai

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P2860

Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups

Rapid evolution of a protein in vitro by DNA shuffling

DNA shuffling of a family of genes from diverse species accelerates directed evolution

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking.

Evolution of a human immunodeficiency virus type 1 variant with enhanced replication in pig-tailed macaque cells by DNA shuffling

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5887-5911

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10.1128/JVI.00254-08

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12

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82

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2008-04-09T00:00:00Z

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5451613

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18400866

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P921

vector-borne disease

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2395137

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