SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response. - Wikidata - awgldk - TriplyDB

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.

http://www.wikidata.org/entity/Q33331870

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Insidious changes in stromal matrix fuel cancer progression Environmental chemical exposures and human epigenetics Loss of SPARC in bladder cancer enhances carcinogenesis and progression.Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer.SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer.KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression.Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.Insufficient maintenance DNA methylation is associated with abnormal embryonic development.Aberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancer.Genomic and epigenomic integration identifies a prognostic signature in colon cancer Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets Anti-cancer role of SPARC, an inhibitor of adipogenesis A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication.Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis Aberrant methylation of secreted protein, acidic and rich in cysteine in human laryngeal and hypopharyngeal carcinoma.Epigenetics and colorectal cancer pathogenesis SPARC expression and prognostic value in non-small cell lung cancer.Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer SPARC: a matricellular regulator of tumorigenesis.SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin.Roles of SPARC in urothelial carcinogenesis, progression and metastasis.Epigenetic biomarkers in colorectal cancer diagnostics.Stromal expression of SPARC in pancreatic adenocarcinoma.Role of SPARC in bone remodeling and cancer-related bone metastasis.Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis.DNA methylation of tumor suppressor protein-coding and non-coding genes in multiple myeloma.Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma.Secreted protein acidic and rich in cysteine inhibits the growth of human pancreatic cancer cells with G1 arrest induction.Decorin gene upregulation mediated by an adeno-associated virus vector increases intratumoral uptake of nab-paclitaxel in neuroblastoma via inhibition of stabilin-1.Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region.Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis.Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination.Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients.Epigenetics and Precision Oncology.Epigenetic silencing of SMOC1 in traditional serrated adenoma and colorectal cancer.

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SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.

http://www.wikidata.org/entity/Q33331870

description

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SPARC promoter hypermethylatio ...... and improve therapy response.

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SPARC promoter hypermethylatio ...... and improve therapy response.

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SPARC promoter hypermethylatio ...... and improve therapy response.

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SPARC promoter hypermethylatio ...... and improve therapy response.

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P2860

Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

CpG island methylator phenotype in colorectal cancer

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix

Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines

Lessons from hereditary colorectal cancer

SPARC, a matricellular glycoprotein with important biological functions

The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis

Mutations in the p53 gene occur in diverse human tumour types

SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells

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