Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
about
What do human parasites do with a chloroplast anyway?Inhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesAlteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by FosmidomycinA sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasitesFosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathwaysFive questions about non-mevalonate isoprenoid biosynthesisLipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacyThe nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by DxsKinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)A comparative analysis of methylome profiles of Campylobacter jejuni sheep abortion isolate and gastroenteric strains using PacBio data.Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria.Fragment screening of infectious disease targets in a structural genomics environmentMutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathwayApicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.Methanogen communities in stools of humans of different age and health status and co-occurrence with bacteria.Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically RedundantResistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporter.Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicidaMolecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Divergent Isoprenoid Biosynthesis Pathways in Staphylococcus Species Constitute a Drug Target for Treating Infections in Companion AnimalsThe effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.Isoprenoid biosynthesis in Plasmodium falciparum.Isoprenoid metabolism in apicomplexan parasites.Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis.Molecular cloning, characterization and expression analysis of the gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Aquilaria sinensis (Lour.) Gilg.Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1From Zn to Mn: the study of novel manganese-binding groups in the search for new drugs against tuberculosis.Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine.A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.Cloning and characterization of 2-C-methyl-D-erythritol-4-phosphate pathway genes for isoprenoid biosynthesis from Indian ginseng, Withania somnifera.NMR studies of DOXP reductoisomerase and its inhibitor complex.
P2860
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P2860
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@ast
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@en
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@nl
type
label
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@ast
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@en
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@nl
prefLabel
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@ast
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@en
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@nl
P2860
P356
P1433
P1476
Dxr is essential in Mycobacter ...... ce is due to a lack of uptake.
@en
P2093
Amanda C Brown
Tanya Parish
P2860
P2888
P356
10.1186/1471-2180-8-78
P577
2008-05-20T00:00:00Z
P5875
P6179
1038133444