A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases.
about
Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311Urzymology: experimental access to a key transition in the appearance of enzymesWhat RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental AttentionFunctional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same GeneLeucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogensOn origin of genetic code and tRNA before translationOne ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylationThe Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement without Ordered Ground-State Tertiary Structures.High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.Tryptophanyl-tRNA synthetase Urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementationPhylogeny of Toll-like receptor signaling: adapting the innate response.New functions of aminoacyl-tRNA synthetases beyond translation.Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation.tRNA acceptor stem and anticodon bases form independent codes related to protein folding.Development of tRNA synthetases and connection to genetic code and disease.Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases.Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues.Aminoacylating urzymes challenge the RNA world hypothesisFull implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular couplingEnhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif.Autocatalytic sets in a partitioned biochemical network.On primordial sense-antisense coding.A master switch couples Mg²⁺-assisted catalysis to domain motion in B. stearothermophilus tryptophanyl-tRNA SynthetaseWhat Froze the Genetic Code?A conformational transition state accompanies tryptophan activation by B. stearothermophilus tryptophanyl-tRNA synthetase.Mg2+-assisted catalysis by B. stearothermophilus TrpRS is promoted by allosteric effects.Whence the genetic code? Thawing the 'frozen accident'.Mg2+-free Bacillus stearothermophilus tryptophanyl-tRNA synthetase retains a major fraction of the overall rate enhancement for tryptophan activation.No rosetta stone for a sense-antisense origin of aminoacyl tRNA synthetase classes.Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding.Fusion with anticodon binding domain of GluRS is not sufficient to alter the substrate specificity of a chimeric Glu-Q-RS.Computational design of fully overlapping coding schemes for protein pairs and triplets.The phylogenomic roots of modern biochemistry: origins of proteins, cofactors and protein biosynthesis.Coding of Class I and II Aminoacyl-tRNA Synthetases.On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases.Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases.
P2860
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P2860
A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@ast
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@en
type
label
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@ast
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@en
prefLabel
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@ast
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@en
P2093
P1433
P1476
A minimal TrpRS catalytic doma ...... II aminoacyl-tRNA synthetases.
@en
P2093
Brian Kuhlman
Charles W Carter
Glenn L Butterfoss
Violetta Weinreb
P304
P356
10.1016/J.MOLCEL.2007.02.010
P577
2007-03-01T00:00:00Z