An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
about
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson SyndromeDevelopment of a fluorescence-based, ultra high-throughput screening platform for nanoliter-scale cytochrome p450 microarrays.Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.A high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450sEffect of Repeated Wuniu Early Tea Administration on the CYP450 Activity Using a Cocktail Method.Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.Recent development in high-throughput bioanalytical support for in vitro ADMET profiling.Sample reduction strategies in discovery bioanalysis.High-throughput fluorescence assay of cytochrome P450 3A4Rapid and accurate liquid chromatography and tandem mass spectrometry method for the simultaneous quantification of ten metabolic reactions catalyzed by hepatic cytochrome P450 enzymes.ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyHigh-throughput fluorescence assay of cytochrome P450 3A4.Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.Evaluation of CYP2C9 Activity in Rats: Use of Tolbutamide Alone and in Combined with Bupropion.Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis.Development of a high-performance, enterprise-level, multimode LC-MS/MS autosampler for drug discovery.Highly Sensitive LC-MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats.High Performance Liquid Chromatographic Determination of Sertraline in Presence of Its Degradation Product
P2860
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P2860
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@ast
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@en
type
label
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@ast
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@en
prefLabel
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@ast
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@en
P2093
P1476
An automated, high-throughput, ...... resolution LC-MS/MS end-point.
@en
P2093
Barry C Jones
Kenneth Saunders
Kuresh A Youdim
Leon Payne
Richard Lyons
P356
10.1016/J.JPBA.2008.05.011
P577
2008-05-17T00:00:00Z