Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
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A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomerDiscovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.
P2860
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Heterotropic activation of the ...... levant drug-drug interactions.
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Heterotropic activation of the ...... levant drug-drug interactions.
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type
label
Heterotropic activation of the ...... levant drug-drug interactions.
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Heterotropic activation of the ...... levant drug-drug interactions.
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Heterotropic activation of the ...... levant drug-drug interactions.
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Heterotropic activation of the ...... levant drug-drug interactions.
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P2093
P2860
P50
P356
P1476
Heterotropic activation of the ...... levant drug-drug interactions.
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P2093
Anna L Blobaum
Carrie K Jones
Claire Mackie
Frank W Byers
Gregor J Macdonald
Hilde Lavreysen
J Scott Daniels
José M Bartolomé
Margrith E Mattmann
Mark L Turlington
P2860
P304
P356
10.1124/DMD.113.052662
P577
2013-09-03T00:00:00Z